Early Onset of Daunomycin Cardiotoxicity in a Case of Acute Myelogeneous Leukemia Associated with Sweet's Syndrome

A patient of acute leukemia with Sweet's syndrome who developed heart failure after receiving 107 mg/㎡ daunorubicin was reported. There seemed to be genetic factors of individuals in inducing anthracycline cardiotoxicity. Further study on genetic analysis of such a disease will be necessary for clarification of the genetic factors susceptible to anthracyclines.This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture

Ultrashort-pulse laser calligraphy

Control of structural modifications inside silica glass by changing the front tilt of an ultrashort pulse is demonstrated, achieving a calligraphic style of laser writing. The phenomena of anisotropic bubble formation at the boundary of an irradiated region and modification transition from microscopic bubbles formation to self-assembled form birefringence are observed, and the physical mechanisms are discussed. The results provide the comprehensive evidence that the light beam with centrosymmetric intensity distribution can produce noncentrosymmetric material modifications

13CO(J=1-0) On-the-fly Mapping of the Giant HII Region NGC 604: Variation in Molecular Gas Density and Temperature due to Sequential Star Formation

We present 13CO(J=1-0) line emission observations with the Nobeyama 45-m telescope toward the giant HII region NGC 604 in the spiral galaxy M 33. We detected 13CO(J=1-0) line emission in 3 major giant molecular clouds (GMCs) labeled as GMC-A, B, and C beginning at the north. We derived two line intensity ratios, 13CO(J=1-0)/12CO(J =1-0), R13/12, and 12CO(J=3-2)/12CO(J =1-0), R31, for each GMC at an angular resolution of 25" (100 pc). Averaged values of R13/12 and R31 are 0.06 and 0.31 within the whole GMC-A, 0.11 and 0.67 within the whole GMC-B, and 0.05 and 0.36 within the whole GMC-C, respectively. In addition, we obtained R13/12=0.09\pm0.02 and R31=0.76\pm0.06 at the 12CO(J=1-0) peak position of the GMC-B. Under the Large Velocity Gradient approximation, we determined gas density of 2.8 \times10^3 cm^-3 and kinetic temperature of 33+9-5 K at the 12CO(J=1-0) peak position of the GMC-B. Moreover, we determined 2.5 \times10^3 cm^-3 and 25\pm2 K as averaged values within the whole GMC-B. We concluded that dense molecular gas is formed everywhere in the GMC-B because derived gas density not only at the peak position of the GMC but also averaged over the whole GMC exceeds 10^3 cm^-3. On the other hand, kinetic temperature averaged over the whole GM-B, 25 K, is significantly lower than that at the peak position, 33 K. This is because HII regions are lopsided to the northern part of the GMC-B, thus OB stars can heat only the northern part, including the 12CO(J=1-0) peak position, of this GMC.Comment: 16 pages, 7 figures, PASJ in pres

Extremal lorentzian surfaces with null r-Planar geodesics in space forms

We show a congruence theorem for oriented Lorentzian surfaces with horizontal reflector lifts in pseudo-Riemannian space forms of neutral signature. As a corollary, a charactcrization theorem is obtained for the Lorentzian Boruvka spheres, that is, a full real analytic null r-planar geodesic immersion with vanishing mean curvature vector field is locally congruent to the Lorentzian Boruvka sphere in a 2r-dimensional space form of neutral signature.出版者照会

Convex Grid Drawings of Plane Graphs with Rectangular Contours

In a convex drawing of a plane graph, all edges are drawn as straight-line segments without any edge-intersection and all facial cycles are drawn as convex polygons. In a convex grid drawing, all vertices are put on grid points. A plane graph G has a convex drawing if and only if G is internally triconnected, and an internally triconnected plane graph G has a convex grid drawing on an n × n grid if G is triconnected or the triconnected component decomposition tree T (G) of G has two or three leaves, where n is the number of vertices in G. In this paper, we show that an internally triconnected plane graph G has a convex grid drawing on a 2n × n 2 grid if T (G) has exactly four leaves. We also present an algorithm to find such a drawing in linear time. Our convex grid drawing has a rectangular contour, while most of the known algorithms produce grid drawings having triangular contours

NRO M33 All-Disk Survey of Giant Molecular Clouds (NRO MAGiC): II. Dense Gas Formation within Giant Molecular Clouds in M33

We report the results of our observations of the 12CO (J=1-0) and 12CO (J=3-2) line emission of 74 major giant molecular clouds (GMCs) within the galactocentric distance of 5.1 kpc in the Local Group galaxy M33. The observations have been conducted as part of the Nobeyama Radio Observatory M33 All-disk survey of Giant Molecular Clouds project (NRO MAGiC). The spatial resolutions are 80 pc for 12CO (J=1-0) and 100 pc for 12CO (J=3-2). We detect 12CO (J=3-2) emission of 65 GMCs successfully. Furthermore, we find that the correlation between the surface density of the star formation rate, which is derived from a linear combination of Halpha and 24um emissions, and the 12CO (J=3-2) integrated intensity still holds at this scale. This result show that the star-forming activity is closely associated with warm and dense gases that are traced with the 12CO (J=3-2) line, even in the scale of GMCs. We also find that the GMCs with a high star-forming activity tend to show a high integrated intensity ratio (R3-2/1-0). Moreover, we also observe a mass-dependent trend of R3-2/1-0 for the GMCs with a low star-forming activity. From these results, we speculate that the R3-2/1-0 values of the GMCs with a low star-forming activity mainly depend on the dense gas fraction and not on the temperature, and therefore, the dense gas fraction increases with the mass of GMCs, at least in the GMCs with a low star-forming activity.Comment: 17 pages, 5 figures, Accepted for publication in PASJ, 2012, Vol. 64, No.

Multilayer aberration correction for depth-independent three-dimensional crystal growth in glass by femtosecond laser heating

Focused femtosecond lasers are known for their ability to modify transparent materials well below the surface with 3D selectivity, but spherical aberration causes degraded focal intensity and undesirable absorption conditions as focal depth increases. To eliminate such effects we have implemented an aberration correction procedure that accounts for multiple refracting layers in order to crystallize LaBGeO5 glass inside a temperature-controlled microscope stage via irradiation through a silica glass window. The correction, applied by a spatial light modulator, was effective at removing the focal depth-dependent degradation and achieving consistent heating conditions at different depths, an important consideration for patterning single-crystal architecture in 3D. Additional effects are noted, which produce a range of crystal cross-section shapes and varying degrees of partial crystallization of the melt